Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction

dc.contributor.author	Ruiz Narváez, Edward A.
dc.contributor.author	Sacks, Frank M.
dc.contributor.author	Campos, Hannia
dc.date.accessioned	2016-07-12T19:33:45Z
dc.date.available	2016-07-12T19:33:45Z
dc.date.issued	2008
dc.identifier.issn	1938-3207
dc.identifier.uri	http://biblioteca.ccp.ucr.ac.cr/handle/123456789/1122
dc.description.abstract	The plasma concentration of apolipoprotein (apo) C-III is a strong predictor of the risk of coronary heart disease (CHD) (1, 2). Apo C-III impairs the clearance of apo B lipoproteins from plasma, which results in an increase in plasma triacylglycerol concentrations (3–7) and directly activates atherosclerotic and inflammatory pathways in vascular cells (8, 9). Therefore, genetic variation affecting the expression of the APOC3 gene may alter apo C-III metabolism and influence CHD. Minor alleles of the 3238C - G (SstI site), -482C-T, and -455T-C polymorphisms are associated with higher plasma triacylglycerol (10–13) and apo C-III (14) concentrations and with an increased risk of CHD (13, 15–17).	en
dc.language.iso	en	en
dc.publisher	American Society for Nutrition	en
dc.rights	Atribución-NoComercial-CompartirIgual 3.0 Costa Rica	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/cr/	*
dc.subject	Enfermedades cardiovasculares	es
dc.subject	Obesidad	es
dc.title	Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction	en
dc.title.alternative	Am J Clin Nutr. 87	en
dc.type	Article	en